UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON D.C. 20549

                                  ------------


                                    FORM 8-K


                                 CURRENT REPORT
                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934


Date of report (Date of earliest event reported):  February 15, 2006


                              The Medicines Company
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               (Exact Name of Registrant as Specified in Charter)


          Delaware                     000-31191                04-3324394
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(State or Other Jurisdiction          (Commission              (IRS Employer
      of Incorporation)               File Number)           Identification No.)


              8 Campus Drive
           Parsippany, New Jersey                                 07054
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   (Address of Principal Executive Offices)                     (Zip Code)

Registrant's telephone number, including area code: (973) 656-1616



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          (Former Name or Former Address, if Changed Since Last Report)

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

     |_| Written communications pursuant to Rule 425 under the Securities
Act (17 CFR 230.425)

     |_| Soliciting material pursuant to Rule 14a-12 under the Exchange
Act (17 CFR 240.14a-12)

     |_| Pre-commencement communications pursuant to Rule 14d-2(b) under the
Exchange Act (17 CFR 240.14d-2(b))

     |_| Pre-commencement communications pursuant to Rule 13e-4(c) under the
Exchange Act (17 CFR 240.13e-4(c))





Item 2.02. Results of Operations and Financial Condition.

     On February 15, 2006, The Medicines Company (the "Company") announced
financial results for the quarter and year ended December 31, 2005. The full
text of the press release issued in connection with the announcement is
furnished as Exhibit 99.1 to this Current Report on Form 8-K.

     The information in this Form 8-K (including Exhibit 99.1) shall not be
deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934
(the "Exchange Act") or otherwise subject to the liabilities of that section,
nor shall it be deemed incorporated by reference in any filing under the
Securities Act of 1933 or the Exchange Act, except as expressly set forth by
specific reference in such a filing.

Item 9.01. Financial Statements and Exhibits

       (c)     Exhibits

               The following exhibit relating to Item 2.02 shall be deemed to be
               furnished, and not filed:

               99.1  Press Release dated February 15, 2006 entitled "The
                     Medicines Company Reports Fourth Quarter and Full Year 2005
                     Financial Results"





                                   SIGNATURES


     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                          THE MEDICINES COMPANY


Date:  February 15, 2006                  By:  /s/ Steven H. Koehler
                                               ---------------------
                                               Steven H. Koehler
                                               Senior Vice President
                                               and Chief Financial Officer





                                  Exhibit Index


Exhibit No.              Description
-----------              -----------

99.1                     Press release dated February 15, 2006 entitled "The
                         Medicines Company Reports Fourth Quarter and Full Year
                         2005 Financial Results"