Ownership Submission
FORM 5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Form 3 Holdings Reported
Form 4 Transactions Reported
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person *
SHROTRIYA RAJESH C MD
 2. Issuer Name and Ticker or Trading Symbol
SPECTRUM PHARMACEUTICALS INC [SPPI] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chairman, CEO & President
(Last)
(First)
(Middle)

11500 S. EASTERN AVE., SUITE 240		 3. Statement for Issuer's Fiscal Year Ended (Month/Day/Year)
12/31/2011
(Street)


HENDERSON, NV 89052		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Reporting
(check applicable line)

_X_ Form Filed by One Reporting Person
___ Form Filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned at end of Issuer's Fiscal Year
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Amount (A) or (D) Price
Common Stock, $.001 Par Value 01/12/2011   G(1) 4,030 D $ 0 2,554,011 D  
Common Stock, $.001 Par Value 08/09/2011   G(2) 3,354 D $ 0 2,554,011 D  
Common Stock, $.001 Par Value 12/28/2011   G(3) 50,000 D $ 0 2,554,011 D  
Common Stock, $.001 Par Value 12/28/2011   G(4) 50,000 A $ 0 2,554,011 I By Self (4)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 2270 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned at End of Issuer's Fiscal Year
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
(A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy) $ 4.23 10/04/2011   G(5)   90,750 01/01/2009 01/01/2016 Common Stock
90,750
$ 0 0
D
 
Stock Option (right to buy) $ 4.23 10/04/2011   G(5) 90,750   01/01/2009 01/01/2016 Common Stock
90,750
$ 0 90,750
I
By Spouse (5)
Stock Option (right to buy) $ 5.08 10/04/2011   G(5)   150,000 09/26/2009 09/26/2016 Common Stock
150,000
$ 0 0
D
 
Stock Option (right to buy) $ 5.08 10/04/2011   G(5) 150,000   09/26/2009 09/26/2016 Common Stock
150,000
$ 0 150,000
I
By Spouse (5)
Stock Option (right to buy) $ 5.53 10/04/2011   G(5)   332,015 01/01/2010 01/01/2017 Common Stock
332,015
$ 0 0
D
 
Stock Option (right to buy) $ 5.53 10/04/2011   G(5) 332,015   01/01/2010 01/01/2017 Common Stock
332,015
$ 0 332,015
I
By Spouse (5)
Stock Option (right to buy) $ 3.15 10/04/2011   G(5)   100,000 12/06/2010 12/06/2017 Common Stock
100,000
$ 0 0
D
 
Stock Option (right to buy) $ 3.15 10/04/2011   G(5) 100,000   12/06/2010 12/06/2017 Common Stock
100,000
$ 0 100,000
I
By Spouse (5)
Stock Option (right to buy) $ 2.55 10/04/2011   G(5)   500,000 03/25/2009 03/25/2018 Common Stock
500,000
$ 0 0
D
 
Stock Option (right to buy) $ 2.55 10/04/2011   G(5) 500,000   03/25/2009 03/25/2018 Common Stock
500,000
$ 0 500,000
I
By Spouse (5)
Stock Option (right to buy) $ 4.23 10/04/2011   G(6)   38,498 01/01/2009 01/01/2016 Common Stock
38,498
$ 0 0
D
 
Stock Option (right to buy) $ 4.23 10/04/2011   G(6) 38,498   01/01/2009 01/01/2016 Common Stock
38,498
$ 0 38,498
I
By Spouse (6)
Stock Option (right to buy) $ 6.09 10/04/2011   G(6)   375,000 06/26/2011 06/26/2019 Common Stock
375,000
$ 0 0
D
 
Stock Option (right to buy) $ 6.09 10/04/2011   G(6) 375,000   06/26/2011 06/26/2019 Common Stock
375,000
$ 0 375,000
I
By Spouse (6)
Stock Option (right to buy) $ 4.65 10/04/2011   G(6)   250,000 01/08/2011 01/08/2020 Common Stock
250,000
$ 0 0
D
 
Stock Option (right to buy) $ 4.65 10/04/2011   G(6) 250,000   01/08/2011 01/08/2020 Common Stock
250,000
$ 0 250,000
I
By Spouse (6)
Stock Option (right to buy) $ 3.92 10/04/2011   G(6)   250,000 07/01/2011 07/01/2020 Common Stock
250,000
$ 0 0
D
 
Stock Option (right to buy) $ 3.92 10/04/2011   G(6) 250,000   07/01/2011 07/01/2020 Common Stock
250,000
$ 0 250,000
I
By Spouse (6)
Stock Option (right to buy) $ 6.87 10/04/2011   G(6)   250,000 01/03/2011 01/03/2021 Common Stock
250,000
$ 0 0
D
 
Stock Option (right to buy) $ 6.87 10/04/2011   G(6) 250,000   01/03/2011 01/03/2021 Common Stock
250,000
$ 0 250,000
I
By Spouse (6)
Stock Option (right to buy) $ 8.27 10/04/2011   G(6)   125,000 06/12/2011 06/12/2021 Common Stock
125,000
$ 0 0
D
 
Stock Option (right to buy) $ 8.27 10/04/2011   G(6) 125,000   06/12/2011 06/12/2021 Common Stock
125,000
$ 0 125,000
I
By Spouse (6)

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
SHROTRIYA RAJESH C MD
11500 S. EASTERN AVE.
SUITE 240
HENDERSON, NV 89052		   X     Chairman, CEO & President  

Signatures

Brett L. Scott, attorney-in-fact for Rajesh C. Shrotriya 02/14/2012
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This transaction involved a gift of securities by the reporting person to his adult children, who do not share the reporting person's household. The reporting person disclaims beneficial ownership of the shares held by his adult children, and this report should not be deemed an admission that the reporting person is the beneficial owner of his children's shares for purposes of Section 16 or any other purpose.
(2) This transaction involved a gift of securities by the reporting person to a trust for the benefit of his grandson, who does not share the reporting person's household. The reporting person disclaims beneficial ownership of the shares held by this trust, and this report should not be deemed an admission that the reporting person is the beneficial owner of the trust's shares for purposes of Section 16 or any other purpose.
(3) This transaction involved a gift of securities by the reporting person to the Shrotriya Family Foundation, a Nevada nonprofit corporation, changing the reporting person's ownership form from direct to indirect.
(4) The Shrotriya Family Foundation, a Nevada Nonprofit corporation, received the shares as a gift from the reporting person who serves as a director and officer of the Shrotriya Family Foundation.
(5) Transfer for estate planning purposes. Indirect beneficial ownership through spouse, as trustee of the Shrotriya Gift Trust.
(6) Transfer for estate planning purposes. Indirect beneficial ownership through spouse, as trustee of the Shrotriya Annuity Trust.

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