Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Esfandiari Javan
 2. Date of Event Requiring Statement (Month/Day/Year)
04/23/2007		 3. Issuer Name and Ticker or Trading Symbol
CHEMBIO DIAGNOSTICS, INC. [CEMI]
(Last)
(First)
(Middle)
3661 HORSEBLOCK ROAD		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP, Research & Development
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

MEDFORD, NY 11763		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock (1) 220,073
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock option right to buy 04/23/2007(2) 04/23/2012 Common Stock 100,000 $ 0.599 D  
Stock option right to buy 03/05/2008(2) 04/23/2012 Common Stock 100,000 $ 0.599 D  
Stock option right to buy 03/05/2009(2) 04/23/2012 Common Stock 100,000 $ 0.599 D  
Stock option right to buy 04/17/2006 12/31/2008 Common Stock 5,000 $ 0.75 D  
Stock option right to buy 04/17/2006 03/31/2008 Common Stock 30,000 $ 0.75 D  
Stock option right to buy 05/28/2007 05/28/2011 Common Stock 25,000 $ 0.75 D  
Stock option right to buy 05/28/2006 05/28/2011 Common Stock 25,000 $ 0.75 D  
Stock option right to buy 04/17/2006 05/04/2011 Common Stock 5,000 $ 0.75 D  
Stock option right to buy 04/17/2006 05/28/2011 Common Stock 25,000 $ 0.75 D  
Stock option right to buy 04/17/2006 05/17/2010 Common Stock 25,000 $ 0.75 D  
Stock option right to buy 01/01/2007 05/17/2010 Common Stock 25,000 $ 0.75 D  
Stock option right to buy 05/05/2004 05/04/2011 Common Stock 30,000 $ 0.75 D  
Stock option right to buy 03/24/2006 03/24/2011 Common Stock 18,750 $ 0.62 D  
Stock option right to buy 01/01/2007 03/24/2011 Common Stock 18,750 $ 0.62 D  
Warrant to purchase stock 05/05/2004 05/04/2009 Common Stock 2,007 $ 0.9 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Esfandiari Javan
3661 HORSEBLOCK ROAD
MEDFORD, NY 11763		       VP, Research & Development  

Signatures

Javan Esfandiari 05/03/2007
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Mr. Esfandiari was granted 200,000 shares of Common Stock on April 23, 2007, 100,000 of these shares vested on April 23, 2007 and 50,000 shares vest on each of March 5, 2008 and March 5, 2009.
(2) Mr. Esfandiari was granted stock options to purchase 300,000 shares of Common Stock on April 23, 2007, 100,000 of these options vested on April 23, 2007 and 100,000 stock options vest on each of March 5, 2008 and March 5, 2009.

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