UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1)*

                         SPECTRUM PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)


                         Common Stock, $0.001 Par Value
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    84763A108
                                    ---------
                                 (CUSIP Number)

                                December 31, 2007
                                -----------------
                      (Date of Event which Requires Filing
                               of this Statement)



Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                  [ ]      Rule 13d-1(b)
                  [X]      Rule 13d-1(c)
                  [ ]      Rule 13d-1(d)



  *The remainder of this cover page shall be filled out for a reporting person's
  initial filing on this form with respect to the subject class of securities,
  and for any subsequent amendment containing information which would alter the
  disclosures provided in a prior cover page.

  The information required on the remainder of this cover page shall not be
  deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
  Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
  the Act but shall be subject to all other provisions of the Act (however, see
  the Notes).


                                  Page 1 of 8





----------------------------                             -----------------------
CUSIP No. 84763A108                      13G             Page 2 of 8 Pages
----------------------------                             -----------------------

---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           CR Intrinsic Investors, LLC
---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a) [ ]
                                                                       (b) [X]
---------- ---------------------------------------------------------------------
3          SEC USE ONLY
---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
-------------------- ------ ----------------------------------------------------
                      5      SOLE VOTING POWER
                             0
                     ------ ----------------------------------------------------
NUMBER OF SHARES      6      SHARED VOTING POWER
BENEFICIALLY OWNED           0  (see Item 4)
BY EACH REPORTING    ------ ----------------------------------------------------
PERSON WITH           7      SOLE DISPOSITIVE POWER
                             0
                     ------ ----------------------------------------------------
                      8      SHARED DISPOSITIVE POWER
                             0 (see Item 4)
---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           0 (see Item 4)
---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           [ ]
---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
           0% (see Item 4)
---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON*
           00
---------- ---------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 2 of 8



----------------------------                             -----------------------
CUSIP No. 84763A108                      13G             Page 3 of 8 Pages
----------------------------                             -----------------------

---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Sigma Capital Management, LLC
---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a) [ ]
                                                                       (b) [X]
---------- ---------------------------------------------------------------------
3          SEC USE ONLY
---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
-------------------- ------ ----------------------------------------------------
                      5      SOLE VOTING POWER
                             0
                     ------ ----------------------------------------------------
NUMBER OF SHARES      6      SHARED VOTING POWER
BENEFICIALLY OWNED           0  (see Item 4)
BY EACH REPORTING    ------ ----------------------------------------------------
PERSON WITH           7      SOLE DISPOSITIVE POWER
                             0
                     ------ ----------------------------------------------------
                      8      SHARED DISPOSITIVE POWER
                             0 (see Item 4)
---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           0 (see Item 4)
---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           [ ]
---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
           0% (see Item 4)
---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON*
           00
---------- ---------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 3 of 8



----------------------------                             -----------------------
CUSIP No. 84763A108                      13G             Page 4 of 8 Pages
----------------------------                             -----------------------

---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Steven A. Cohen
---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a) [ ]
                                                                       (b) [X]
---------- ---------------------------------------------------------------------
3          SEC USE ONLY
---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
-------------------- ------ ----------------------------------------------------
                      5      SOLE VOTING POWER
                             0
                     ------ ----------------------------------------------------
NUMBER OF SHARES      6      SHARED VOTING POWER
BENEFICIALLY OWNED           0  (see Item 4)
BY EACH REPORTING    ------ ----------------------------------------------------
PERSON WITH           7      SOLE DISPOSITIVE POWER
                             0
                     ------ ----------------------------------------------------
                      8      SHARED DISPOSITIVE POWER
                             0 (see Item 4)
---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           0 (see Item 4)
---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           [ ]
---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
           0% (see Item 4)
---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON*
           IN
---------- ---------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 4 of 8




Item 1(a)           Name of Issuer:
                    --------------

                    Spectrum Pharmaceuticals, Inc.

Item 1(b)           Address of Issuer's Principal Executive Offices:
                    -----------------------------------------------

                    157 Technology Drive, Irvine California 92618

Items 2(a)          Name of Person Filing:
                    ---------------------

                    This statement is filed by: (i) CR Intrinsic Investors, LLC
                    ("CR Intrinsic Investors") with respect to shares of common
                    stock, $0.001 par value ("Shares"), of the Issuer
                    beneficially owned by CR Intrinsic Investments, LLC ("CR
                    Intrinsic Investments"); (ii) Sigma Capital Management, LLC
                    ("Sigma Management") with respect to Shares beneficially
                    owned by Sigma Capital Associates, LLC ("Sigma Capital
                    Associates") and (iii) Steven A. Cohen with respect to
                    Shares beneficially owned by CR Intrinsic Investors, CR
                    Intrinsic Investments, Sigma Management and Sigma Capital
                    Associates.

Item 2(b)           Address of Principal Business Office:
                    ------------------------------------

                    The address of the principal business office of (i) CR
                    Intrinsic Investors and Mr. Cohen is 72 Cummings Point Road,
                    Stamford, Connecticut 06902 and (ii) Sigma Management is 540
                    Madison Avenue, New York, New York 10022.

Item 2(c)           Citizenship:
                    -----------

                    CR Intrinsic Investors and Sigma Management are Delaware
                    limited liability companies. Mr. Cohen is a United States
                    citizen.

Item 2(d)           Title of Class of Securities:
                    ----------------------------

                    Common Stock, $0.001 par value

Item 2(e)           CUSIP Number:
                    ------------

                    84763A108

Item 3              Not Applicable

                                  Page 5 of 8




Item 4              Ownership:

                    As of the close of business on December 31, 2007:

                    1. CR Intrinsic Investors, LLC
                    (a) Amount beneficially owned: -0-
                    (b) Percent of class: 0%
                    (c)(i) Sole power to vote or direct the vote: -0-
                    (ii) Shared power to vote or direct the vote: -0-
                    (iii) Sole power to dispose or direct the disposition: -0-
                    (iv) Shared power to dispose or direct the disposition: -0-

                    2. Sigma Capital Management, LLC
                    (a) Amount beneficially owned: -0-
                    (b) Percent of class: 0%
                    (c)(i) Sole power to vote or direct the vote: -0-
                    (ii) Shared power to vote or direct the vote: -0-
                    (iii) Sole power to dispose or direct the disposition: -0-
                    (iv) Shared power to dispose or direct the disposition: -0-

                    3. Steven A. Cohen
                    (a) Amount beneficially owned: -0-
                    (b) Percent of class: 0%
                    (c)(i) Sole power to vote or direct the vote: -0-
                    (ii) Shared power to vote or direct the vote: -0-
                    (iii) Sole power to dispose or direct the disposition: -0-
                    (iv) Shared power to dispose or direct the disposition: -0-

                    CR Intrinsic Investors, Sigma Management and Mr. Cohen do
                    not directly own any Shares. Pursuant to an investment
                    management agreement, CR Intrinsic Investors maintains
                    investment and voting power with respect to the securities
                    held by CR Intrinsic Investments. Pursuant to an investment
                    management agreement, Sigma Management maintains investment
                    and voting power with respect to the securities held by
                    Sigma Capital Associates. Mr. Cohen controls each of CR
                    Intrinsic Investors and Sigma Management. Each of CR
                    Intrinsic Investors, Sigma Management and Mr. Cohen disclaim
                    beneficial ownership of any of the securities covered by
                    this statement.

                                  Page 6 of 8



Item 5              Ownership of Five Percent or Less of a Class:
                    --------------------------------------------

                    If this statement is being filed to report the fact that as
                    of the date hereof the reporting person has ceased to be the
                    beneficial owner of more than five percent of the class of
                    securities, check the following.   [X]

Item 6              Ownership of More than Five Percent on Behalf of Another
                    --------------------------------------------------------
                    Person:
                    ------

                    Not Applicable

Item 7              Identification and Classification of the
                    ----------------------------------------
                    Subsidiary Which Acquired the Security Being
                    --------------------------------------------
                    Reported on By the Parent Holding Company:
                    -----------------------------------------

                    Not Applicable

Item 8              Identification and Classification of Members
                    --------------------------------------------
                    of the Group:
                    ------------

                    Not Applicable

Item 9              Notice of Dissolution of Group:
                    ------------------------------

                    Not Applicable

Item 10             Certification:
                    -------------

         By signing below the signatory certifies that, to the best of his
knowledge and belief, the securities referred to above were not acquired and are
not held for the purpose of or with the effect of changing or influencing the
control of the issuer of the securities and were not acquired and are not held
in connection with or as a participant in any transaction having that purpose or
effect.

                                  Page 7 of 8




                                    SIGNATURE
                                    ---------

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated:  February 14, 2008


CR INTRINSIC INVESTORS, LLC


By:     /s/ Peter Nussbaum
        ---------------------------------
Name:   Peter Nussbaum
Title:  Authorized Person


SIGMA CAPITAL MANAGEMENT, LLC


By:     /s/ Peter Nussbaum
        ---------------------------------
Name:   Peter Nussbaum
Title:  Authorized Person


STEVEN A. COHEN


By:     /s/ Peter Nussbaum
        ---------------------------------
Name:   Peter Nussbaum
Title:  Authorized Person


                                  Page 8 of 8