UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                 SCHEDULE 13G/A
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 1)*

                         SPECTRUM PHARMACEUTICALS, INC.
                                (Name of Issuer)

                          COMMON STOCK, $.001 PAR VALUE
                         (Title of Class of Securities)

                                    84763A108
                                 (CUSIP Number)

                                  JULY 20, 2007
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

|_|      Rule 13d-1(b)
|X|      Rule 13d-1(c)
|_|      Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).



PERSONS WHO ARE TO RESPOND TO THE COLLECTION OF INFORMATION CONTAINED IN THIS
FORM ARE NOT REQUIRED TO RESPOND UNLESS THE FORM DISPLAYS A CURRENTLY VALID OMB
CONTROL NUMBER.

SEC 1745 (12-02)







                         

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         CUSIP No. 84763A108                            13G/A                             Page 2 of 8 Pages
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--------- ------------------------------------------------------------------------------------------------------------
1.
          NAMES OF REPORTING PERSONS
          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

          PERCEPTIVE ADVISORS LLC

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--------- ------------------------------------------------------------------------------------------------------------
2.
          CHECK THE APPROPRIATE BOX IF A GROUP*                                                            (a)
                                                                                                           (b) |X|
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--------- ------------------------------------------------------------------------------------------------------------
3.        SEC USE ONLY



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4.
          CITIZENSHIP OR PLACE OF ORGANIZATION

          DELAWARE

--------- ------------------------------------------------------------------------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
    NUMBER OF       5.
      SHARES              SOLE VOTING POWER                                                                         0
------------------- ----- --------------------------------------------- ----------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
   BENEFICIALLY     6.
     OWNED BY             SHARED VOTING POWER                                                                 312,696
------------------- ----- --------------------------------------------- ----------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
       EACH         7.
    REPORTING             SOLE DISPOSITIVE POWER                                                                    0
------------------- ----- --------------------------------------------- ----------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
   PERSON WITH:     8.
                          SHARED DISPOSTIVE POWER                                                             312,696
------------------- ----- --------------------------------------------- ----------------------------------------------
--------- ---------------------------------------------------------------------------- -------------------------------
9.
          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                                        312,696
--------- ---------------------------------------------------------------------------- -------------------------------
--------- ------------------------------------------------------------------------------------------------------------
10.
          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
--------- ------------------------------------------------------------------------------------------------------------
--------- ---------------------------------------------------------------------------- -------------------------------
11.
          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                                                     1.02%
--------- ---------------------------------------------------------------------------- -------------------------------
--------- ---------------------------------------------------------------------------- -------------------------------
12.
          TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)                                                    IA
--------- ---------------------------------------------------------------------------- -------------------------------





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         CUSIP No. 84763A108                            13G/A                             Page 3 of 8 Pages
--------------------------------------- --------------------------------------- --------------------------------------


--------- ------------------------------------------------------------------------------------------------------------
13.
          NAMES OF REPORTING PERSONS
          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

          JOSEPH EDELMAN

--------- ------------------------------------------------------------------------------------------------------------
--------- ------------------------------------------------------------------------------------------------------------
14.
          CHECK THE APPROPRIATE BOX IF A GROUP*                                                            (a)
                                                                                                           (b) |X|
--------- ------------------------------------------------------------------------------------------------------------
--------- ------------------------------------------------------------------------------------------------------------
15.       SEC USE ONLY



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--------- ------------------------------------------------------------------------------------------------------------
16.
          CITIZENSHIP OR PLACE OF ORGANIZATION

          UNITED STATES OF AMERICA

--------- ------------------------------------------------------------------------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
    NUMBER OF       17.
      SHARES              SOLE VOTING POWER                                                                         0
------------------- ----- --------------------------------------------- ----------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
   BENEFICIALLY     18.
     OWNED BY             SHARED VOTING POWER                                                                 312,696
------------------- ----- --------------------------------------------- ----------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
       EACH         19.
    REPORTING             SOLE DISPOSITIVE POWER                                                                    0
------------------- ----- --------------------------------------------- ----------------------------------------------
------------------- ----- --------------------------------------------- ----------------------------------------------
   PERSON WITH:     20.
                          SHARED DISPOSTIVE POWER                                                             312,696
------------------- ----- --------------------------------------------- ----------------------------------------------
--------- ---------------------------------------------------------------------------- -------------------------------
21.
          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                                        312,696
--------- ---------------------------------------------------------------------------- -------------------------------
--------- ------------------------------------------------------------------------------------------------------------
22.
          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
--------- ------------------------------------------------------------------------------------------------------------
--------- ---------------------------------------------------------------------------- -------------------------------
23.
          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)                                                     1.02%
--------- ---------------------------------------------------------------------------- -------------------------------
--------- ---------------------------------------------------------------------------- -------------------------------
24.
          TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)                                                    IN
--------- ---------------------------------------------------------------------------- -------------------------------






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CUSIP No. 84763A108                                      13G/A                             Page 4 of 8 Pages
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ITEM 1.
        (a) Name of Issuer:                                  Spectrum Pharmaceuticals, Inc.


                                                             157 Technology Drive
        (b) Address of Issuer's Principal Executive Offices: Irvine, California
92618

ITEM 2.

                                   This Schedule 13G/A is being filed with
                                   respect to shares of Common Stock of the
(a) Name of Person Filing:         Issuer which are beneficially owned by
                                   Perceptive Advisors LLC and Joseph Edelman.
                                   See Item 4 below.

                                                                     Perceptive Advisors LLC
                                                                     499 Park Avenue, 25th Floor
(b) Address of Principal Business Office or, if none, Residence:     New York, NY 10022

                                   Perceptive Advisors LLC is a Delaware limited
(c) Citizenship:                   liability company and Joseph Edelman is a
                                   United States Citizen (d) Title of Class of
                                   Securities: Common Stock, $.001 par value

(e)CUSIP Number:                   84763A108



ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO SS.SS.240.13D-1(B) OR
            240.13D-2(B) OR (C), CHECK WHETHER THE PERSON FILING IS A:

        (a) [ ] Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
        (b) [ ] Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
        (c) [ ] Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).
        (d) [ ] Investment  company  registered  under section 8 of the Investment  Company Act of 1940 (15 U.S.C
                80a-8).
        (e) [ ] An investment adviser in accordance with ss.240.13d-1(b)(1)(ii)(E);
        (f) [ ] An employee benefit plan or endowment fund in accordance with ss.240.13d-1(b)(1)(ii)(F);
        (g) [ ] A parent holding company or control  person in accordance with ss. 240.13d-1(b)(1)(ii)(G);
        (h) [ ] A savings associations as defined in Section 3(b) of the Federal Deposit Insurance
                Act (12  U.S.C. 1813);
        (i) [ ] A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the
                Investment Company Act of 1940 (15 U.S.C. 80a-3);
        (j)[ ]  Group, in accordance with ss.240.13d-1(b)(1)(ii)(J).










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CUSIP No. 84763A108                                      13G/A                             Page 5 of 8 Pages
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ITEM 4.          OWNERSHIP.

          Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

                                   Mr. Edelman beneficially owns: 312,696 shares
                                   of Common Stock held by Perceptive Life
(a) Amount beneficially owned:     Sciences Master Fund Ltd. ("Master Fund"), a
                                   Cayman Islands company of which the
                                   investment manager is Perceptive Advisors
                                   LLC, a Delaware limited liability company of
                                   which Mr. Edelman is the managing member.

(b) Percent of class:               Mr. Edelman: 1.02%
                                   Perceptive Advisors LLC: 1.02%

                                   The aggregate percentage of shares reported
                                   owned by each person named herein is based
                                   upon 30,805,259 shares outstanding which is
                                   the total number of shares outstanding as of
                                   May 24, 2007 as reported by the Issuer on the
                                   Form 8-K as filed with the Securities and
                                   Exchange Commission on May 24, 2007.









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CUSIP No. 84763A108                                      13G/A                            Page 6 of 8 Pages
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     (c) Number of shares as to which the person has:
                                                                                  Perceptive Advisors LLC: 0
                                                                                  Mr. Edelman: 0
                   (i) Sole power to vote or to direct the vote:
                                                                                  Perceptive Advisors LLC: 312,696

                   (ii)     Shared power to vote or to direct the vote:           Mr. Edelman: 312,696

                                                                                  Perceptive Advisors LLC: 0
                            Sole power to  dispose  or to direct the  disposition
                  (iii)     of:                                                   Mr. Edelman: 0

                                                                                  Perceptive Advisors LLC: 312,696
                   (iv) Shared power to dispose or to direct the disposition
                            of:                                                   Mr. Edelman: 312,696
ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS


If this statement is being filed to report the fact that as of the date hereof
the reporting person has ceased to be the beneficial owner of more than five
percent of the class of securities, check the following [X]

ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

Not applicable.

ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY OR CONTROL PERSON.

See Exhibit B

ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

Not applicable.






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CUSIP No. 84763A108                                      13G/A                            Page 7 of 8 Pages
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ITEM 9. NOTICE OF DISSOLUTION OF GROUP.


Not applicable.
ITEM 10.  CERTIFICATION

                 The following certification shall be included if the statement
is filed pursuant to ss.240.13d-1(b):

                                   By signing below I certify that, to the best
                                   of my knowledge and belief, the securities
                                   referred to above were acquired and are held
                                   in the ordinary course of business and were
(a)                                not acquired and are not held for the purpose
                                   of or with the effect of changing or
                                   influencing the control of the issuer of the
                                   securities and were not acquired and are not
                                   held in connection with or as a participant
                                   in any transaction having that purpose or
                                   effect. [X]







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CUSIP No. 84763A108                                      13G/A                            Page 8 of 8 Pages
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                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


August 8, 2008
Date

/s/ Perceptive Advisors LLC
Signature

Joseph Edelman/Managing Member
Name/Title

August 8, 2008
Date

/s/ Joseph Edelman
Signature

Joseph Edelman
Name/Title

The original statement shall be signed by each person on whose behalf the
statement is filed or his authorized representative. If the statement is signed
on behalf of a person by his authorized representative other than an executive
officer or general partner of the filing person, evidence of the
representative's authority to sign on behalf of such person shall be filed with
the statement, provided, however, that a power of attorney for this purpose
which is already on file with the Commission may be incorporated by reference.
The name and any title of each person who signs the statement shall be typed or
printed beneath his signature.

NOTE: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. SEE ss.240.13d-7 for other
parties for whom copies are to be sent.

ATTENTION:    INTENTIONAL MISSTATEMENTS OR OMISSIONS OF FACT CONSTITUTE FEDERAL CRIMINAL VIOLATIONS (SEE 18 U.S.C. 1001)







                                  EXHIBIT LIST

Exhibit A   Joint Filing Agreement
Exhibit B   Item 7 Statement

                                    EXHIBIT A

            The undersigned hereby agree jointly to prepare and file with
regulatory authorities a Schedule 13G/A and any amendment thereto reporting each
of the undersigned's ownership of securities of Spectrum Pharmaceuticals, Inc.
and hereby affirm that such Schedule 13G/A is being filed on behalf of each of
the undersigned.


August 8, 2008
Date

/s/ Perceptive Advisors LLC
Signature

Joseph Edelman/Managing Member
Name/Title

August 8, 2008
Date

/s/ Joseph Edelman
Signature

Joseph Edelman
Name/Title


                                    EXHIBIT B

            As discussed in Item 4(a), certain shares reported herein are held
through Perceptive Life Sciences Master Fund Ltd., a Cayman Islands company, of
which Joseph Edelman is the managing member of Perceptive Advisors LLC, the
Master Fund's investment manager.