CTD HOLDINGS, INC.

                              27317 NW 78th Avenue

                           High Springs, Florida 32643

                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS

                                November 22, 2004

The Annual Meeting of Shareholders of CTD Holdings,  Inc., a Florida corporation
(the  "Company"),  will be held at  27317  NW 78th  Avenue,  in the city of High
Springs,  Florida 32643,  on Monday,  November 22, 2004, at 10:00 AM local time,
for the transaction of the following business:

(1)  To elect directors to the Board of Directors of the Company.

(2)  To ratify the selection of James Moore & Co. as the  Company's  independent
     auditor for the fiscal year 2005.

(3)  To transact such other  business as may properly come before the meeting or
     any adjournment or adjournments thereof.


The Board of Directors  has fixed the close of business on October 27, 2004,  as
the record date for the determination of stockholders who are entitled to notice
of, and to vote at, the Annual  Meeting and/or any  adjournment or  adjournments
thereof.  Only  holders of record of Common  Stock at the close of  business  on
October  27,  2004,  will be  entitled  to notice of, and to vote at, the Annual
Meeting and/or any adjournment or adjournments thereof.

In order to assure that your interests will be  represented,  whether or not you
plan to attend the Annual Meeting in person, please complete,  date and sign the
enclosed form of proxy and return it promptly in the enclosed envelope.

By Order of the Board of Directors

/s/ C.E. Rick Strattan
C.E. Rick Strattan
President

October 29, 2004



                               CTD HOLDINGS, INC.

                              27317 NW 78th Avenue

                           High Springs, Florida 32643

                        (386) 454-0887 Fax (386) 454-8134

                             E-mail ctd@cyclodex.com

                                 PROXY STATEMENT

                         ANNUAL MEETING OF SHAREHOLDERS

                                November 22, 2004

This proxy statement and accompanying form of proxy will be mailed to holders of
Common  Shares on or about  October 29, 2004.  They are  furnished in connection
with the solicitation by the Board of Directors  (hereinafter sometimes referred
to as the "Board") of CTD Holdings,  Inc. (hereinafter  sometimes referred to as
the "Company"),  of proxies for use at the Annual Meeting of Shareholders of the
Company  to be held on  November  22,  2004,  at 10:00 AM EST,  at 27317 NW 78th
Avenue,  High Springs,  Florida 32643,  and at any  adjournment or  adjournments
thereof.

At the Annual Meeting, the shareholders of the Company will be asked to consider
and vote (1) to approve  the  election of two (2)  directors  to serve until the
next annual  meeting and (2) to ratify the selection of James Moore & Co. as the
Company's  independent  auditor for the fiscal year 2005. The Board of Directors
recommends you vote "FOR" these proposals.

                               VOTING INFORMATION

The Board of Directors  has fixed the close of business on October 27, 2004,  as
the record date for determination of shareholders  entitled to notice of, and to
vote at, the Annual Meeting and at any adjournment  thereof.  Accordingly,  only
holders of record of common  shares at the close of  business on the record date
will be  entitled  to receive  notice of,  and to vote at, the  meeting.  On any
matter which may properly  come before the meeting,  holders of common shares of
record on the record  date are  entitled  to one vote per  share.  On the record
date, October 27, 2004, 6,478,984 common shares representing 6,478,984 votes and
one share of Series A Preferred  representing  6,743,400 votes,  were issued and
outstanding.

Shareholders  who do not plan to be present at the Annual  Meeting are requested
to date and sign the enclosed form of proxy and return it in the return envelope
provided.  All common  shares which are  represented  at the meeting by properly
executed  proxies  received  prior to or at the meeting and not revoked  will be
voted in  accordance  with the  instructions  indicated in such  proxies.  If no
instructions  are  indicated,  such proxies will be voted "FOR"  election of the
nominees  listed  therein as  directors of the Company who will  constitute  the
entire Board of Directors of the Company,  and "FOR"  ratifying the selection of
James Moore & Co. as the Company's auditors for the 2005 fiscal year.

Under applicable provisions of the Florida Business Corporation Act, business to
be  considered at the Annual  Meeting is confined to that business  described in
the  notice of meeting to which this proxy  statement  is  attached.  Thus,  the
matters to come before the meeting will be limited to those matters described in
the notice.  All proxies presented at the Annual Meeting,  whether given to vote
in favor of or against the foregoing  proposals,  will,  unless contrary written
instructions  are noted on the form of proxy,  also entitle the persons named in
such proxy to vote such proxies in their  discretion  on any proposal to adjourn
the meeting or otherwise concerning the conduct of the meeting.

Shareholders  have the right to revoke their  proxies by notifying the Secretary
of the  Company  in  writing  at any time  prior to the time the  common  shares
represented  thereby are  actually  voted.  Proxies may be revoked by (i) filing
with the  Secretary  of the  Company,  before  the  vote is taken at the  Annual
Meeting,  either a written  notice of  revocation  bearing a later date than the
proxy, or a duly executed proxy relating to the same shares bearing a later date
than the other proxy,  or (ii) attending the Annual Meeting and voting in person
(although  attendance  at the  meeting  will not in and of itself  constitute  a
revocation of a proxy).  Any written notice revoking a proxy or subsequent proxy
should  be sent to CTD  Holdings,  Inc.,  27317 NW 78th  Avenue,  High  Springs,
Florida 32643, Attention: Secretary.

Under the applicable  provisions of the Florida Business Corporation Act and the
Company's  By-Laws,  if a quorum  is  present,  the  favorable  vote of a simple
majority  of the votes cast by holders of Common  Stock,  voting in person or by
proxy,  at the Annual  Meeting  will be required in order to approve the matters
referred to in proposals (1) and (2) below.

                       PROPOSAL 1 - ELECTION OF DIRECTORS

Two (2) directors, constituting the entire Board of Directors, is proposed to be
elected  to serve  until the next  Annual  Meeting of  shareholders,  or until a
successor shall be elected and shall qualify. The following persons are proposed
to be nominated:

                              Principal Occupation                    Year First
                              and Other Major                           Became

Name, Age             Age       Affiliations                            Director

C.E. Rick Strattan     58       President, CEO and Chairman               1990

George L. Fails        57       Operations Manager                        2001

C.E. Rick Strattan,  President, CEO and Director since 1990. Mr. Strattan served
as treasurer of the Company from August,  1990, to May, 1995. From November 1987
through July 1992, Mr.  Strattan was with  Pharmatec,  Inc.,  where he served as
Director of  Marketing  and  Business  Development  for CDs.  Mr.  Strattan  was
responsible  for  CD  sales  and  related  business  development  efforts.  From
November, 1985 through May, 1987, Mr. Strattan served as Chief Technical Officer
for Boots-Celltech Diagnostics, Inc. He also served as Product Sales Manager for
American  Bio-Science  Laboratories,  a Division  of  American  Hospital  Supply
Corporation. Mr. Strattan is a graduate of the University of Florida receiving a
B.S. degree in chemistry and mathematics,  and has also received an MS degree in
Pharmacology, and an MBA degree in Marketing/Computer Information Sciences, from
the same institution.  Mr. Strattan has written and published  numerous articles
and a book chapter on the subject of Cyclodextrins.

George L. Fails,  Operations  Manager CTD, Inc. since 2000. Mr. Fails  currently
serves as  Operations  Manager for CTD, Inc.  Prior to joining the Company,  Mr.
Fails served as a Detective Sergeant with the Veterans  Administration  Hospital
in Gainesville,  Florida,  with special duties as a Predator Officer with the US
Marshall's  Service.  From 1965 until his  retirement in 1986,  Mr. Fails served
with the US Army Special Forces,  including several tours in Viet Nam, Salvador,
and Angola.  Mr. Fails also served two years with a United  States  intelligence
arm. Mr. Fails received his BA from the University of the  Philippines,  and has
also received  degrees from 43 Military  schools,  as well as the Federal Police
Academy in Little Rock, Arkansas.

The principal  occupation of the nominees during at least the last five years is
that shown in the table  above.  If the  nominees for  directors  should  become
unavailable  for election (which the Board of Directors has no reason to believe
will be the case),  the shares  represented  by the enclosed proxy will be voted
for such substitute nominees as may be nominated by the Board of Directors.

Directors,  including directors also serving the Company in another capacity and
receiving separate compensation  therefore shall be entitled to receive from the
Company  as  compensation  for  their  services  as  directors  such  reasonable
compensation  as the board may from time to time  determine,  and shall  also be
entitled to  reimbursements  for any reasonable  expenses  incurred in attending
meetings  of  directors.  To  date,  the  Board of  Directors  has  received  no
compensation, and no attendance fees have been paid.

The Board of Directors  recommends that all shareholders  vote "FOR" approval of
the two nominees to the Company's Board of Directors.

                PROPOSAL 2 - RATIFICATION OF INDEPENDENT AUDITORS

The Audit Committee has selected James Moore & Co. as the Company's  independent
auditor for the 2005 fiscal year, and the Board is asking shareholders to ratify
that  selection.  Although  current law, rules and  regulations,  as well as the
charter of the Audit Committee,  require the Company's independent auditor to be
engaged, retained and supervised by the Audit Committee, the Board considers the
selection of the  independent  auditor to be an important  matter of shareholder
concern and is submitting the selection of James Moore & Co. for ratification by
shareholders as a matter of good corporate practice.

The  affirmative  vote of holders of a  majority  of the shares of common  stock
represented  at the  meeting is  required  to approve  the  ratification  of the
selection  of James  Moore & Co. as the  Company's  independent  auditor for the
current fiscal year.

The  Board  of  Directors  recommends  that  all  shareholders  vote  "FOR"  the
ratification of James Moore & Co. as the Company's  independent auditors for the
2005 fiscal year.

                             OWNERSHIP OF SECURITIES

Our voting  securities are currently  comprised of our common stock. The holders
of our  shares of common  stock are  entitled  to one vote for each  outstanding
share on all matters submitted to our shareholders. The following table contains
information  regarding record  ownership of our voting  securities as of October
28, 2004 held by persons who own  beneficially  more than 5% of our  outstanding
common stock; our directors;  named executive officers; and all of our directors
and officers as a group.

A person is deemed to be the beneficial owner of securities that can be acquired
by such a person  within 60 days from June 30,  2004 upon  exercise  of options,
warrants or convertible securities. Each beneficial owner's percentage ownership
is determined by assuming that options, warrants and convertible securities that
are held by such a person  (but not  those  held by any  other  person)  and are
exercisable within 60 days from that date have been exercised.  Unless otherwise
indicated,  the address of each of the listed  beneficial  owners  identified is
27317 N.W. 78 Avenue, High Springs, Florida 32643.

Name of                      Amount and Nature of       Percentage    Percentage
Beneficial Owner             Beneficial Ownership       Common         Preferred

C.E. Rick Strattan(1)        1,400,051 Common             20.78%
                             1 Series A Preferred                          100%

George L. Fails (2)          140,464 Common                2.00%             0%


All officers and directors   1,540,515 Common             22.78%
as a group (two persons)     1 Series A Preferred                          100%



(1) The  shares of  common  stock  beneficially  owned by Mr.  Strattan  include
502,318 shares which are issuable to Mr.  Strattan  pursuant to the terms of his
2004 employment agreement.

(2) The shares of common stock  beneficially owned by Mr. Fails includes 100,464
shares  which  are  issuable  to  Mr.  Fails   pursuant  to  the  terms  of  his
2004employment agreement.

                   COMPLIANCE WITH SEC REPORTING REQUIREMENTS

Under  the  securities  laws of the  United  States,  the  Company's  directors,
executive  officers,  and any  persons  holding  more than five  percent  of the
Company's  Common Stock are required to report  their  initial  ownership of the
Company's  Common  Stock and any  subsequent  changes in their  ownership to the
Securities  and  Exchange  Commission  ("SEC").  Specific  due  dates  have been
established  by the SEC,  and the  Company is required to disclose in this Proxy
Statement  any  failure  to file by those  dates.  Based  upon (i) the copies of
Section 16(a) reports that the Company received from such persons for their 2003
fiscal year transactions and (ii) the written representations  received from one
or more of such persons that no annual Form 5 reports were  required to be filed
for them for the 2003  fiscal  year,  the Company  believes  that there has been
compliance  with  all  Section  16(a)  filing  requirements  applicable  to such
officers, directors, and five-percent beneficial owners for such fiscal year.

                 EXECUTIVE COMPENSATION AND RELATED INFORMATION

The Board of Directors sets the  compensation  of the Chief  Executive  Officer,
reviews the design,  administration  and effectiveness of compensation  programs
for other key  executives,  and approves  stock option  grants for all executive
officers.  The Board of Directors believes that compensation  programs should be
designed to attract,  motivate  and retain  talented  executives,  and should be
determined  within a  competitive  framework  and  based on the  achievement  of
designated financial targets, individual contribution, customer satisfaction and
financial performance relative to that of the Company's competitors. Within this
overall philosophy,  the Company's objectives are to: Offer a total compensation
program that takes into  consideration the compensation  practices of a group of
peer companies and other selected  companies with which the Company competes for
executive  talent (the "Peer  Companies");  Provide  annual  variable  incentive
awards that take into account the Company's  overall  financial  performance  in
terms of designated corporate  objectives,  as well as individual  contributions
and customer  satisfaction;  Align the financial interests of executive officers
with those of  shareholders  by providing  significant  equity-based,  long-term
incentives.  The three  major  components  of the  Company's  executive  officer
compensation are: (i) base salary,  (ii) variable  incentive  awards,  and (iii)
long-term,  equity-based  incentive  awards.  The base salary for each executive
officer is determined at levels considered  appropriate for comparable positions
at Peer  Companies.  To reinforce the attainment of Company goals,  the Board of
Directors believes that a substantial portion of the annual compensation of each
executive officer should be in the form of variable  incentive pay. The Board of
Directors  evaluates Company performance based on both revenue and profit before
interest and taxes that must be attained before any incentives are awarded.  The
Board of Directors  determines  the size of long-term,  equity-based  incentives
according to each  executive's  position  within the Company and sets a level it
considers appropriate to create a meaningful opportunity for stock ownership. In
addition,  the Board of  Directors  takes into  account an  individual's  recent
performance,  potential for future responsibility and promotion,  and the number
of unvested options held by each individual at the time of the new grant.

                 SUMMARY OF CASH AND CERTAIN OTHER COMPENSATION

The following table sets forth the compensation  earned,  by the Company's Chief
Executive  Officers for services  rendered in all  capacities to the Company and
its  subsidiaries  for each of the last  three  fiscal  years.  The  individuals
included in the table will be collectively referred to as the "Named Officers."


                           SUMMARY COMPENSATION TABLE

           (three fiscal years ended December 31, 2000, 2001 and 2003)

                                    Annual                                            Long-Term
                               Compensation                                         Compensation

                                                                           Other Annual          All Other

Name and Position          Year             Salary            Bonus        Compensation          Compensation
-------------------------------------------------------------------------------------------------------------
                                                                                    

C.E. Rick Strattan         2003             $ 36,000          -0-          $50,000               $  -0-(1)
President, CEO             2002             $ 33,346          -0-          -0-                   $  -0-
Chairman                   2001             $      835        -0-          -0-                   $ 59,687(2)

George L. Fails            2003             $ 20,836          -0-          -0-                   $  -0-
Operations Manager         2002             $ 20,000          -0-          -0-                   $  -0-
                           2001             $ 20,000          -0-          -0-                   $  -0-


(1) Reflects grants of 1,000,000 shares
(2) Reflects grants of 800,000 shares

On October 14, 2003, the Company  entered into a one-year  Employment  Agreement
with C.E.  Rick  Strattan,  the  Company's  president,  with an annual salary of
$36,000 and $5,000 per month in restricted common shares of the Company based on
80% of the closing value of the Company's shares on the last day of the month in
which the  shares are  awarded.  No shares  were  awarded  under the  Employment
Agreement in 2003.  As of September 30, 2004,  502,318  shares have been awarded
pursuant to the  Employment  Agreement.  The Company has agreed to register  Mr.
Strattan's shares awarded pursuant to his employment contract.

Effective  January 1,  2004,  the  Company  entered  into a one-year  Employment
Agreement  with George L. Fails to serve as  Operations  Manager.  Mr.  Fails is
compensated $1,900 monthly, plus $1,000 per month in restricted common shares of
the Company,  based on 80% of the closing value of the  Company's  shares on the
last day of the month in which the shares are awarded. As of September 30, 2004,
100,464 shares have been awarded pursuant to the Employment Agreement.

On November 17,  2003,  the Company  entered  into an  agreement  with Big Apple
Consulting  of Longwood,  Florida,  to provide  PR/IR and  financial  consulting
services.  The term of the contract was for six months. Mr. Strattan transferred
500,000 common shares held by him to Big Apple as a consulting fee.

                 SHAREHOLDER PROPOSALS FOR 2004 PROXY STATEMENT

Shareholder  proposals that are intended to be presented at the Company's Annual
Meeting of  Shareholders  to be held in 2005 must be  received by the Company no
later than July 1, 2005,  in order to be  included  in the proxy  statement  and
related proxy materials.  Please send any such proposals to CTD Holdings,  Inc.,
27317 NW 78th Avenue, in the city of High Springs, Florida 32643, Attn: Investor
Relations.  In addition,  the proxy  solicited by the Board of Directors for the
2005 Annual Meeting of Shareholders will confer discretionary  authority to vote
on any shareholder proposal presented at that meeting.

                                   FORM 10-KSB

THE COMPANY WILL MAIL FOR THE COST OF POSTAGE,  UPON WRITTEN REQUEST,  A COPY OF
THE COMPANY'S  ANNUAL  REPORT ON FORM 10-KSB FOR THE FISCAL YEAR ENDED  DECEMBER
31, 2003, INCLUDING THE FINANCIAL STATEMENTS,  SCHEDULES,  AND LIST OF EXHIBITS.
REQUESTS SHOULD BE SENT TO CTD HOLDINGS, INC., 27317 NW 78th AVENUE, IN THE CITY
OF HIGH SPRINGS, FLORIDA 32643, ATTN: INVESTOR RELATIONS.

                                  OTHER MATTERS

The Board knows of no other  matters to be presented for  shareholder  action at
the Annual Meeting. However, if other matters do properly come before the Annual
Meeting or any adjournments or postponements thereof, the Board intends that the
persons  named in the proxies  will vote upon such  matters in  accordance  with
their best judgment.

Proxies are being solicited by and on behalf of the Board of Directors. The cost
of  soliciting  these  proxies will be borne by the Company.  In addition to the
solicitation  of these proxies by mail, the Company will request banks,  brokers
and other record  holders to send proxies and proxy  material to the  beneficial
owners of the stock and secure  their voting  instructions.  If  necessary,  the
Company may also use individuals,  who will not be specifically compensated,  to
solicit proxies from shareholders,  either personally or by telephone,  telegram
or letter.  The Board and officers are not aware of any other  matters which may
be presented  for action at the meeting,  but if other  matters do properly come
before the meeting, it is intended that the shares of Common Stock,  represented
by proxies in the  accompanying  form will be voted by the persons  named in the
proxy in accordance with their best judgment.

You are cordially invited to attend this meeting.  However,  whether you plan to
attend the  meeting or not,  you are  respectfully  urged to sign and return the
enclosed  proxy,  which may be revoked if you are  present at the meeting and so
request.

CTD HOLDINGS, INC.

/s/ C.E. Rick Strattan

C.E. Rick Strattan
President

October 29, 2004



                                      PROXY

                               CTD Holdings, INC.

            This Proxy is Solicited by the Board of Directors for the

           Annual Meeting of Shareholders to be Held November 22, 2004

The  undersigned  hereby appoints C.E. Rick Strattan,  with individual  power of
substitution  and  revocation,  to vote all common shares of CTD Holdings,  Inc.
(the  "Corporation")  which  the  undersigned  would be  entitled  to  vote,  if
personally  present at the Annual Meeting of shareholders to be held at 27317 NW
78th Avenue,  in the city of High Springs,  Florida 32643, on November 22, 2004,
and any adjournment  thereof,  upon matters  indicated below as described in the
Notice of Annual Meeting of Shareholders and accompanying  Proxy Statement dated
October 29, 2004.

This Proxy will be voted in accordance with the instructions as indicated below.
If no instructions are given, this Proxy will be voted "FOR" approval of the two
nominees to the Corporation's Board of Directors,  and "FOR" the ratification of
the selection of James Moore & Co. as the Corporation's independent auditors for
the 2005 fiscal year.

         Please  sign where  indicated  and return  this Proxy  promptly  in the
enclosed envelope.

1.   Election of two (2) Directors: C.E. Rick Strattan and George L. Fails.

                  FOR               AGAINST                ABSTAIN
                      ----------             -----------             -----------

         For all nominees except as noted:

2.   Ratification  of the  selection  of James Moore & Co. as the  Corporation's
     independent auditors for the 2005 fiscal year.

                   FOR              AGAINST                 ABSTAIN
                       -----------           -----------             -----------


Please sign exactly as name appears on address label. Executors, administrators,
guardians, trustees, attorneys, and officers or representatives should give full
title. For joint owners, each owner should sign.

________________________         _________________________________________, 2004
Signature                           Printed Name                       Date


________________________         _________________________________________, 2004
Signature                           Printed Name                       Date