UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 7)*



                         PROGENICS PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)



                                  COMMON STOCK
--------------------------------------------------------------------------------
                         (Title of Class of Securities)



                                    743187106
--------------------------------------------------------------------------------
                                 (CUSIP Number)



                                December 31, 2005
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

     [ ]      Rule 13d-1(b)

     [ ]      Rule 13d-1(c)

     [X]      Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                                     Page 1




CUSIP No.   743187106
            -----------------------
--------------------------------------------------------------------------------
    1)     Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Tudor Investment Corporation
           ---------------------------------------------------------------------
                22-2514825
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------
    2)     Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------

           (b)         X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------
    3)     SEC Use Only
                        --------------------------------------------------------
--------------------------------------------------------------------------------
    4)     Citizenship or Place of Organization   Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                       (5)  Sole Voting Power                       0
                                             -----------------------------------
Number of Shares       ---------------------------------------------------------
Beneficially           (6)  Shared Voting Power             2,107,881
Owned by Each                                  ---------------------------------
Reporting Person       ---------------------------------------------------------
With                   (7)  Sole Dispositive Power                  0
                                                  ------------------------------
                       ---------------------------------------------------------
                       (8)  Shared Dispositive Power        2,107,881
                                                    ----------------------------
--------------------------------------------------------------------------------
    9)     Aggregate Amount Beneficially Owned by Each Reporting
           Person               2,107,881
                  --------------------------------------------------------------
--------------------------------------------------------------------------------
   10)     Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------
   11)     Percent of Class Represented by Amount in Row 9       8.3%
                                                           ---------------------
--------------------------------------------------------------------------------
   12)     Type of Reporting Person (See Instructions)     CO
                                                       -------------------------
--------------------------------------------------------------------------------

                                     Page 2




CUSIP No.   743187106
            -----------------------
--------------------------------------------------------------------------------
    1)     Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Tudor Group Holdings LLC
           ---------------------------------------------------------------------
                13-3862746
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------
    2)     Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------

           (b)         X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------
    3)     SEC Use Only
                        --------------------------------------------------------
--------------------------------------------------------------------------------
    4)     Citizenship or Place of Organization   Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                       (5)  Sole Voting Power                       0
                                             -----------------------------------
Number of Shares       ---------------------------------------------------------
Beneficially           (6)  Shared Voting Power               234,507
Owned by Each                                  ---------------------------------
Reporting Person       ---------------------------------------------------------
With                   (7)  Sole Dispositive Power                  0
                                                  ------------------------------
                       ---------------------------------------------------------
                       (8)  Shared Dispositive Power          234,507
                                                    ----------------------------
--------------------------------------------------------------------------------
    9)     Aggregate Amount Beneficially Owned by Each Reporting
           Person                 234,507
                  --------------------------------------------------------------
--------------------------------------------------------------------------------
   10)     Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------
   11)     Percent of Class Represented by Amount in Row 9       0.9%
                                                           ---------------------
--------------------------------------------------------------------------------
   12)     Type of Reporting Person (See Instructions)     OO
                                                       -------------------------
--------------------------------------------------------------------------------

                                     Page 3




CUSIP No.   743187106
            -----------------------
--------------------------------------------------------------------------------
    1)     Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Paul Tudor Jones, II
           ---------------------------------------------------------------------

           ---------------------------------------------------------------------
--------------------------------------------------------------------------------
    2)     Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------

           (b)         X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------
    3)     SEC Use Only
                        --------------------------------------------------------
--------------------------------------------------------------------------------
    4)     Citizenship or Place of Organization   USA
                                                --------------------------------
--------------------------------------------------------------------------------
                       (5)  Sole Voting Power                 546,125
                                             -----------------------------------
Number of Shares       ---------------------------------------------------------
Beneficially           (6)  Shared Voting Power             2,342,388
Owned by Each                                  ---------------------------------
Reporting Person       ---------------------------------------------------------
With                   (7)  Sole Dispositive Power            546,125
                                                  ------------------------------
                       ---------------------------------------------------------
                       (8)  Shared Dispositive Power        2,342,388
                                                    ----------------------------
--------------------------------------------------------------------------------
    9)     Aggregate Amount Beneficially Owned by Each Reporting
           Person               2,888,513
                  --------------------------------------------------------------
--------------------------------------------------------------------------------
   10)     Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------
   11)     Percent of Class Represented by Amount in Row 9      11.4%
                                                           ---------------------
--------------------------------------------------------------------------------
   12)     Type of Reporting Person (See Instructions)     IN
                                                       -------------------------
--------------------------------------------------------------------------------

                                     Page 4




CUSIP No.   743187106
            -----------------------
--------------------------------------------------------------------------------
    1)     Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Mark F. Dalton
           ---------------------------------------------------------------------

           ---------------------------------------------------------------------
--------------------------------------------------------------------------------
    2)     Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------

           (b)         X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------
    3)     SEC Use Only
                        --------------------------------------------------------
--------------------------------------------------------------------------------
    4)     Citizenship or Place of Organization   USA
                                                --------------------------------
--------------------------------------------------------------------------------
                       (5)  Sole Voting Power                 139,000
                                             -----------------------------------
Number of Shares       ---------------------------------------------------------
Beneficially           (6)  Shared Voting Power             2,358,888
Owned by Each                                  ---------------------------------
Reporting Person       ---------------------------------------------------------
With                   (7)  Sole Dispositive Power            139,000
                                                  ------------------------------
                       ---------------------------------------------------------
                       (8)  Shared Dispositive Power        2,358,888
                                                    ----------------------------
--------------------------------------------------------------------------------
    9)     Aggregate Amount Beneficially Owned by Each Reporting
           Person               2,497,888
                  --------------------------------------------------------------
--------------------------------------------------------------------------------
   10)     Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------
   11)     Percent of Class Represented by Amount in Row 9       9.9%
                                                           ---------------------
--------------------------------------------------------------------------------
   12)     Type of Reporting Person (See Instructions)     IN
                                                       -------------------------
--------------------------------------------------------------------------------

                                     Page 5




CUSIP No.   743187106
            -----------------------
--------------------------------------------------------------------------------
    1)     Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                The Tudor BVI Global Portfolio Ltd.
           ---------------------------------------------------------------------
                98-0223576
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------
    2)     Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------

           (b)         X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------
    3)     SEC Use Only
                        --------------------------------------------------------
--------------------------------------------------------------------------------
    4)     Citizenship or Place of Organization   Cayman Islands
                                                --------------------------------
--------------------------------------------------------------------------------
                       (5)  Sole Voting Power                       0
                                             -----------------------------------
Number of Shares       ---------------------------------------------------------
Beneficially           (6)  Shared Voting Power             1,820,068
Owned by Each                                  ---------------------------------
Reporting Person       ---------------------------------------------------------
With                   (7)  Sole Dispositive Power                  0
                                                  ------------------------------
                       ---------------------------------------------------------
                       (8)  Shared Dispositive Power        1,820,068
                                                    ----------------------------
--------------------------------------------------------------------------------
    9)     Aggregate Amount Beneficially Owned by Each Reporting
           Person               1,820,068
                  --------------------------------------------------------------
--------------------------------------------------------------------------------
   10)     Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------
   11)     Percent of Class Represented by Amount in Row 9       7.2%
                                                           ---------------------
--------------------------------------------------------------------------------
   12)     Type of Reporting Person (See Instructions)     CO
                                                       -------------------------
--------------------------------------------------------------------------------

                                     Page 6




CUSIP No.   743187106
            -----------------------
--------------------------------------------------------------------------------
    1)     Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Tudor Arbitrage Partners L.P.
           ---------------------------------------------------------------------
                13-3496979
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------
    2)     Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------

           (b)         X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------
    3)     SEC Use Only
                        --------------------------------------------------------
--------------------------------------------------------------------------------
    4)     Citizenship or Place of Organization   Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                       (5)  Sole Voting Power                       0
                                             -----------------------------------
Number of Shares       ---------------------------------------------------------
Beneficially           (6)  Shared Voting Power               193,126
Owned by Each                                  ---------------------------------
Reporting Person       ---------------------------------------------------------
With                   (7)  Sole Dispositive Power                  0
                                                  ------------------------------
                       ---------------------------------------------------------
                       (8)  Shared Dispositive Power          193,126
                                                    ----------------------------
--------------------------------------------------------------------------------
    9)     Aggregate Amount Beneficially Owned by Each Reporting
           Person                 193,126
                  --------------------------------------------------------------
--------------------------------------------------------------------------------
   10)     Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------
   11)     Percent of Class Represented by Amount in Row 9       0.8%
                                                           ---------------------
--------------------------------------------------------------------------------
   12)     Type of Reporting Person (See Instructions)     PN
                                                       -------------------------
--------------------------------------------------------------------------------

                                     Page 7





CUSIP No.   743187106
            -----------------------
--------------------------------------------------------------------------------
    1)     Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Tudor Proprietary Trading, L.L.C.
           ---------------------------------------------------------------------
                13-3720063
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------
    2)     Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------

           (b)         X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------
    3)     SEC Use Only
                        --------------------------------------------------------
--------------------------------------------------------------------------------
    4)     Citizenship or Place of Organization   Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                       (5)  Sole Voting Power                       0
                                             -----------------------------------
Number of Shares       ---------------------------------------------------------
Beneficially           (6)  Shared Voting Power                25,981
Owned by Each                                  ---------------------------------
Reporting Person       ---------------------------------------------------------
With                   (7)  Sole Dispositive Power                  0
                                                  ------------------------------
                       ---------------------------------------------------------
                       (8)  Shared Dispositive Power           25,981
                                                    ----------------------------
--------------------------------------------------------------------------------
    9)     Aggregate Amount Beneficially Owned by Each Reporting
           Person                  25,981
                  --------------------------------------------------------------
--------------------------------------------------------------------------------
   10)     Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------
   11)     Percent of Class Represented by Amount in Row 9       0.1%
                                                           ---------------------
--------------------------------------------------------------------------------
   12)     Type of Reporting Person (See Instructions)     OO
                                                       -------------------------
--------------------------------------------------------------------------------

                                     Page 8




CUSIP No.   743187106
            -----------------------
--------------------------------------------------------------------------------
    1)     Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Tudor Global Trading LLC
           ---------------------------------------------------------------------
                13-3862744
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------
    2)     Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------

           (b)         X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------
    3)     SEC Use Only
                        --------------------------------------------------------
--------------------------------------------------------------------------------
    4)     Citizenship or Place of Organization   Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                       (5)  Sole Voting Power                       0
                                             -----------------------------------
Number of Shares       ---------------------------------------------------------
Beneficially           (6)  Shared Voting Power               208,526
Owned by Each                                  ---------------------------------
Reporting Person       ---------------------------------------------------------
With                   (7)  Sole Dispositive Power                  0
                                                  ------------------------------
                       ---------------------------------------------------------
                       (8)  Shared Dispositive Power          208,526
                                                    ----------------------------
--------------------------------------------------------------------------------
    9)     Aggregate Amount Beneficially Owned by Each Reporting
           Person                 208,526
                  --------------------------------------------------------------
--------------------------------------------------------------------------------
   10)     Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------
   11)     Percent of Class Represented by Amount in Row 9       0.8%
                                                           ---------------------
--------------------------------------------------------------------------------
   12)     Type of Reporting Person (See Instructions)     OO
                                                       -------------------------
--------------------------------------------------------------------------------

                                     Page 9




Item 1(a).  Name of Issuer:

            Progenics Pharmaceuticals, Inc.

Item 1(b).  Address of Issuer's Principal Executive Offices:

            777 Old Saw Mill River Road
            Tarrytown, NY 10591

Item 2(a).  Name of Person Filing:

            Tudor Investment Corporation ( "TIC")
            Tudor Group Holdings LLC ( "TGH")
            Paul Tudor Jones, II
            Mark F. Dalton
            The Tudor BVI Global Portfolio Ltd. ( "Tudor BVI")
            Tudor Arbitrage Partners L.P. ( "TAP")
            Tudor Proprietary Trading, L.L.C. ( "TPT")
            Tudor Global Trading LLC ( "TGT")

Item 2(b).  Address of Principal Business Office or, if none, Residence:

            The principal business office of each of TIC, TGH, TAP, TPT and
            TGT is:

                      1275 King Street
                      Greenwich, CT 06831

             The principal business office of each of Messrs. Jones and Dalton
             is:

                      c/o Tudor Investment Corporation
                      1275 King Street
                      Greenwich, CT 06831

            The principal business office of Tudor BVI is:

                      c/o CITCO
                      Kaya Flamboyan 9
                      Curacao, Netherlands Antilles

Item 2(c).  Citizenship:

            TIC is a Delaware corporation
            Tudor BVI is a company organized under the laws of the Cayman
            Islands
            Messrs. Jones and Dalton are citizens of the United States
            TAP is a Delaware limited partnership
            TGH, TPT and TGT are Delaware limited liability companies

                                    Page 10



Item 2(d).  Title of Class of Securities:

            Common Stock

Item 2(e).  CUSIP Number:

            743187106

Item 3.     If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b),
            check whether the person filing is a:

      (a)  [ ] Broker or Dealer registered under Section 15 of the Act
      (b)  [ ] Bank as defined in section 3(a)(6) of the Act
      (c)  [ ] Insurance Company as defined in Section 3(a)(19) of the Act
      (d)  [ ] Investment Company registered under Section 8 of the Investment
               Company Act
      (e)  [ ] Investment Adviser registered under section 203 of the Investment
               Advisers Act of 1940
      (f)  [ ] Employment Benefit Plan, Pension Fund which is subject to the
               provisions of the Employee Retirement Income Security Act of 1974
               or Endowment Fund; see ss.240.13d-1(b)(1)(ii)(F)
      (g)  [ ] Parent Holding Company, in accordance with
               ss.240.13d-1(b)(1)(ii)(G) (Note: See Item 7)
      (h)  [ ] Group, in accordance with ss.240.13d-1(b)(1)(ii)(H)

Item 4. Ownership (as of December 31, 2005).

      (a) Amount Beneficially Owned: See Item 9 of cover pages

      (b) Percent of Class: See Item 11 of cover pages

      (c) Number of shares as to which such person has:

          (i)   sole power to vote or to direct the vote
                                                       See Item 5 of cover pages
                                                       -------------------------
          (ii)   shared power to vote or to direct the vote
                                                       See Item 6 of cover pages
                                                       -------------------------
          (iii)  sole power to dispose or to direct the disposition of
                                                       See Item 7 of cover pages
                                                       -------------------------
          (iv)   shared power to dispose or to direct the disposition of
                                                       See Item 8 of cover pages
                                                       -------------------------

      The shares of common stock ("Shares") reported herein as beneficially
owned are owned directly by Tudor BVI (1,820,068 Shares), TAP (193,126 Shares),
TPT (25,981 Shares), and TGT (15,400 Shares).

      Because TIC provides investment advisory services to Tudor BVI, TIC may be
deemed to beneficially own the Shares owned by Tudor BVI. TIC expressly
disclaims beneficial ownership of such Shares. TGH holds a majority of the
equity interests of TGT and indirectly

                                    Page 11




holds a majority of the membership interests of TPT. TGH is also the sole
limited partner of TAP. TGH expressly disclaims beneficial ownership of the
Shares beneficially owned by each of such entities. TGT, as the sole general
partner of TAP, may be deemed to beneficially own the Shares owned by TAP, and
Mr. Dalton, as the sole general partner of D.F. Partners, a New York limited
partnership, may be deemed to beneficially own the Shares owned by such entity.
Each of TGT and Mr. Dalton expressly disclaim beneficial ownership of such
Shares. Mr. Jones is the Chairman and principal equity owner of TIC and TGH. Mr.
Jones expressly disclaims beneficial ownership of the Shares beneficially owned,
or deemed beneficially owned, by such entities. Mr. Dalton is the President and
an equity owner of TIC and TGH. Mr. Dalton expressly disclaims beneficial
ownership of the Shares beneficially owned, or deemed beneficially owned, by
such entities.

      The Shares reported herein under Items 5 and 7 of Mr. Jones' cover page
include 4,600 Shares held directly by Mr. Jones' individual retirement account.
The Shares reported herein under Items 5 and 7 of Mr. Dalton's cover page
include 65,000 immediately exercisable options.



Item 5.   Ownership of Five Percent or Less of a Class.

            Not applicable

Item 6.   Ownership of More than Five Percent on Behalf of Another Person.

            Not applicable

Item 7.   Identification and Classification of the Subsidiary Which Acquired
          the Security Being Reported on By the Parents Holding Company.

            Not applicable

Item 8.   Identification and Classification of Members of the Group.

            See cover pages

Item 9.   Notice of Dissolution of Group.

            Not applicable

Item 10.  Certification.

            Not applicable

                                    Page 12




        After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                   Dated: February 13, 2006

                                   TUDOR INVESTMENT CORPORATION


                                   By:       /s/ Stephen N. Waldman
                                       -----------------------------------------
                                       Stephen N. Waldman
                                       Managing Director and Associate General
                                         Counsel

                                   TUDOR GROUP HOLDINGS LLC


                                   By:       /s/ Stephen N. Waldman
                                       -----------------------------------------
                                       Stephen N. Waldman
                                       Managing Director and Associate General
                                         Counsel


                                       /s/ Paul Tudor Jones, II
                                   ---------------------------------------------
                                       Paul Tudor Jones, II



                                       /s/ Mark F. Dalton
                                   ---------------------------------------------
                                       Mark F. Dalton

                                   THE TUDOR BVI GLOBAL PORTFOLIO LTD.

                                   By: Tudor Investment Corporation,
                                       Trading Advisor


                                   By:       /s/ Stephen N. Waldman
                                       -----------------------------------------
                                       Stephen N. Waldman
                                       Managing Director and Associate General
                                         Counsel

                                    Page 13




                                   TUDOR ARBITRAGE PARTNERS L.P.

                                   By: Tudor Global Trading LLC,
                                       General Partner


                                   By:       /s/ Stephen N. Waldman
                                       -----------------------------------------
                                       Stephen N. Waldman
                                       Managing Director and Associate General
                                         Counsel

                                   TUDOR PROPRIETARY TRADING, L.L.C.


                                   By:       /s/ Stephen N. Waldman
                                       -----------------------------------------
                                       Stephen N. Waldman
                                       Managing Director and Associate General
                                         Counsel

                                   TUDOR GLOBAL TRADING LLC


                                   By:       /s/ Stephen N. Waldman
                                       -----------------------------------------
                                       Stephen N. Waldman
                                       Managing Director and Associate General
                                         Counsel


                                    Page 14