PROSPECTUS SUPPLEMENT FILED PURSUANT TO RULE 424(B)(4)
   
TO PROSPECTUS DATED MARCH 28, 2001 REGISTRATION NO. 333-37072

GENENTECH, INC.

SHARES OF COMMON STOCK

     This prospectus supplement relates to the sale by certain selling shareholders of our common stock, par value $.02 per share, that was originally delivered in exchange for Liquid Yield Option Notes due 2015 issued by Roche Holdings, Inc.

     This prospectus supplement should be read in conjunction with the prospectus dated March 28, 2001, which is to be delivered with this prospectus supplement. All capitalized terms used but not defined in the prospectus supplement shall have the meanings given them in the prospectus.

     The table below sets forth information as of the date hereof concerning beneficial ownership of the common stock of the selling shareholders as listed below. All information concerning beneficial ownership has been furnished by the selling shareholders.

NAME   NUMBER OF SHARES OF
 COMMON STOCK
 OWNED PRIOR TO
 OFFERING 		  NUMBER OF
 SHARES OFFERED 		  NUMBER OF SHARES OF
 COMMON STOCK
 OWNED AFTER THE
 OFFERING 		  PERCENTAGE OF
 COMMON STOCK
 OUTSTANDING
                 
Goldman, Sachs & Co.
  26,772   26,772   0   *
         
* Less than 1%                

THE SECURITIES OFFERED HEREBY INVOLVE A HIGH DEGREE OF RISK. SEE
“RISK FACTORS” BEGINNING ON PAGE 3 OF THE PROSPECTUS.

THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE
SECURITIES AND EXCHANGE COMMISSION NOR HAS THE SECURITIES AND
EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION PASSED
UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY
REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

The date of this Prospectus Supplement is December 19, 2005.