FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * LABRUM RONALD K   2. Issuer Name and Ticker or Trading Symbol CARDINAL HEALTH INC [CAH] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) CEO-Healthcare Supply Chn Svc (Last) (First) (Middle) 1430 WAUKEGAN ROAD 3. Date of Earliest Transaction (Month/Day/Year) 10/25/2005 (Street) MCGAW PARK, IL 60085 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Shares 10/25/2005   M(1)   1,010 A $ 9.84 37,092 D   Common Shares 10/25/2005   S(1)   1,010 D $ 65 36,082 D   Common Shares               5,764 I By 401(k) plan Common Shares               2,816 I By ESPP

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Option (right to buy) (2)

$ 9.84

10/25/2005

M

0.0071

01/21/1999

10/10/2006

Common Shares

1,010

(5)

0.3262

D

Option (right to buy) (2)

$ 12.25

01/21/1999

11/24/2006

Common Shares

19,554

1

D

Option (right to buy) (3)

$ 47.33

03/01/2002

03/01/2009

Common Shares

18,600

1

D

Option (right to buy) (3)

$ 31.17

11/15/2002

11/15/2009

Common Shares

37,500

1

D

Option (right to buy) (3)

$ 66.083

11/20/2003

11/20/2010

Common Shares

31,500

1

D

Option (right to buy) (3)

$ 68.1

11/19/2004

11/19/2011

Common Shares

44,604

1

D

Option (right to buy) (3)

$ 67.9

11/18/2005

11/18/2012

Common Shares

53,019

1

D

Option (right to buy) (3)

$ 61.38

11/17/2006

11/17/2013

Common Shares

25,000

1

D

Option (right to buy) (3)

$ 61.38

11/17/2006

11/17/2013

Common Shares

60,280

1

D

Option (right to buy) (3)

$ 44.15

08/23/2007

08/23/2014

Common Shares

105,000

1

D

Option (right to buy) (3)

$ 58.88

(4)

09/02/2012

Common Shares

84,288

1

D

Option (right to buy) (3)

$ 62.38

(4)

09/15/2012

Common Shares

84,288

1

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
LABRUM RONALD K 1430 WAUKEGAN ROAD MCGAW PARK, IL 60085			CEO-Healthcare Supply Chn Svc

Signatures

Ronald K. Labrum		10/27/2005
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The exercise and sale reported on this Form 4 were effected pursuant to a 10b5-1 plan adopted by the reporting person on March 10, 2005, when he was not aware of material non-public information about the Company.
(2)	Stock option granted pursuant to the Allegiance Corporation 1996 Incentive Compensation Program.
(3)	Stock option granted pursuant to the Cardinal Health, Inc. Equity Incentive Plan.
(4)	Stock option vests in four equal annual installments beginning on 9/2/2006.
(5)	Stock option was disposed of in connection with its exercise for no additional consideration beyond the option shares.

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