Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
BLAIR JAMES C
   2. Issuer Name and Ticker or Trading Symbol
NUVASIVE INC [NUVA] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O DOMAIN ASSOCIATES, LLC, ONE PALMER SQUARE		 3. Date of Earliest Transaction (Month/Day/Year)
03/08/2007
(Street)

PRINCETON, NJ 08542		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 03/08/2007   J(1)   17,740 (3) A (1) 17,740 I By Domain Associates, LLC (2)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy) $ 10.75 03/08/2007   M     18,000   (4) 02/26/2014 Common Stock 18,000 $ 0 6,000 D (1)  
Stock Option (Right to Buy) $ 10.08 03/08/2007   M     6,000   (5) 01/03/2015 Common Stock 6,000 $ 0 0 D (1)  
Stock Option (Right to Buy) $ 19 03/08/2007   M     6,000   (6) 07/27/2015 Common Stock 6,000 $ 0 0 D (1)  
Stock Option (Right to Buy) $ 18.95 03/08/2007   M     13,000   (7) 03/03/2016 Common Stock 13,000 $ 0 4,000 D (1)  
Stock Option (Right to Buy) $ 16.5 03/08/2007   M     4,500   (8) 05/24/2016 Common Stock 4,500 $ 0 1,500 D (1)  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
BLAIR JAMES C
C/O DOMAIN ASSOCIATES, LLC
ONE PALMER SQUARE
PRINCETON, NJ 08542		   X      

Signatures

 Lisa A. Kraeutler, Attorney-in-Fact   03/09/2007
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Pursuant to the limited liability company agreement of Domain Associates, LLC, of which the Reporting Person is a managing member, upon exercise the shares underlying the options were transferred to Domain Associates, LLC.
(2) The Reporting Person is a managing member of Domain Associates, LLC. Pursuant to Instruction 4(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by such entity. The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his pecuniary interest therein and/or that are not actually distributed to him.
(3) Reflects the net exercise of options, whereby shares were sold to pay the option exercise price at their fair market value on the date of exercise of $23.14.
(4) The option was granted on 2/26/04 and vested 25% on the first anniversary of that date with the balance vesting in 36 monthly installments thereafter.
(5) The option was granted on 1/3/05 and was 100% vested on that date.
(6) The option was granted on 7/27/05 and was 100% vested on the first anniversary of that date.
(7) The option was granted on 3/3/06 and 11,000 shares vested on that date with an additional 2,000 shares vesting on each anniversary thereafter.
(8) The option was granted on 5/24/06 and vests in twelve equal monthly installments beginning on that date.

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